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In contrast, in the presence of 16.7 mM glucose, metformin had no effect on incretininduced cAMP production

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Preliminary results from the SURPASS-J-mono study in Japanese patients with T2D who were either therapy nave or on an antidiabetic monotherapy showed a head-to-head comparison of a tirzepatide treatment compared to therapy with the GLP-1RA dulaglutide at a dose of 0.75 mg (54, 76)

Thanks to all this, it's one of the most commonly used emollients out there